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Similarly, the role of Fra2/BolA2 in human cells is largely unknown, although the mitochondrially targeted BolA3 is involved in FeS cluster acquisition and/or maintenance for some mitochondrial FeS enzymes, especially lipoate synthase (

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In 2020, Mina Lee and colleagues isolated 13 limonoids from Citrus junos seed extract, among which sudachinoid A, a novel compound, and Ichangensin showed promise in treating UC

Damaged mitochondria result in electron leakage, produce increased ROS, and release cytochrome C leading to activation of caspase-3, caspase-9, and other pro-apoptotic factors ultimately leading to cell death (Brustovetsky et al., 2008