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In the first edition of Smart Medicine Investigates, I review what BPC-157 is, what the current science actually shows, where the evidence is promising, andmost importantlywhere significant gaps still exist

Avoid mixing it in the same routine with strong direct acids, retinoids, or strong vitamin C formulas , since commercial copper-peptide products commonly advise against that pairing

Some gastrointestinal issues or loss of appetite may also benefit from a more stable metabolic rate

Mechanism of Action 5-Amino-1MQ exerts its metabolic effects primarily through competitive inhibition of nicotinamide N-methyltransferase (NNMT), an enzyme belonging to the methyltransferase superfamily that is expressed in multiple tissues including liver, adipose tissue, skeletal muscle, kidney, and brain, with particularly high expression in visceral (abdominal) adipose tissue - the fat depot most strongly associated with metabolic disease