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Specifically, we are finalizing with modification revisions to 45 CFR 180.20 to add definitions for tenth (10th) percentile allowed amount, median allowed amount, and ninetieth (90th) percentile allowed amount, which are values a hospital will encode when a payer-specific negotiated charge is based on a percentage or algorithm, to more accurately reflect the distribution of actual amounts that a hospital has received for an item or service

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Besides the main differential characteristics, other negative findings to rule out common causes of true TMA, such as TTP, HUS, DIC, drug-induced TMA, autoimmune-associated TMA, etc., are also essential to guide primary specific management

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