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Mitochondria, being the primary organelles producing ROS within cells, generate ROS that can attack various mitochondrial components, leading to increased mtDNA mutations and oxidative damage to associated respiratory chain enzymes ( mtDNA mutations and aging mtDNA mutations also affect individual and cellular aging, with the accumulation of mtDNA mutations increasing with age ( Genomic instability and aging Genomic instability in the nucleus can influence mitochondrial physiology during aging through so-called anterograde stimulation ( The role of mitochondria in cell death Cell death is a crucial regulatory mechanism for maintaining organismal homeostasis

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