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39 ReeseR

This bond is rigid and predominantly exists in a trans configuration

Peters, A., McEwen, B

As one study showed (133), unconjugated bilirubin disrupts the interaction between C1q and immunoglobulins, thereby suppressing the first step of the classical pathway of complement activation, which is activated by several factors that are cancer-promoting (134136), so this inhibition of the classical pathway may act as a cancer-inhibitor