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FIGURE 3 4.2.2 Regulating mitochondrial function and energy metabolism Mitochondrial dysfunction plays a significant role in ischemic CVD caused by endothelial dysfunction (Song et al., 2013)

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Both studies were conducted in accordance with Good Clinical Practice, the Declaration of Helsinki and US Food and Drug Administration/European Medicines Agency guidelines for studies in people with renal or hepatic impairment [12,13,14,15]