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The study found that after IDH1 mutation, it will catalyze the massive conversion of 2-KG to tumor metabolite 2-HG, while consuming reduced NADPH

Pain Physician 17 , 18 (2014)

Particular emphasis will be placed on exploring the potential mechanisms and clinical applicability of L-citrulline in preserving human sperm function, with the goal of advancing its translation into evidence-based strategies for male reproductive health