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5.1 Oxidative regulation of intracellular signaling pathways Redox-regulated signaling pathways often operate through the reversible oxidation of specific cysteine residues within proteins

Indeed, the GSH and GSH-related enzymatic systems are efficient tools that cells have exploited in detoxification and, at the same time, represent the most ancient notice on the physiological role played by the tripeptide

Enhancing GSH, mainly through NAC, GSH precursors or pro-GSH compound administration, becomes a potential treatment option for SARS-CoV-2 infection and COVID-19 disease by reducing oxidative stress and cytokine expression especially in diabetic patients at risk of more severe disease (Singh et al., 2022)

Understanding alternatives helps researchers choose appropriate compounds for their goals