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Therefore, our results suggest that TMAO accelerates eGFR decline in concert with existing pro-fibrotic signaling (i.e., TGF-1

In this space, we find the pyruvate dehydrogenase complex and various enzymes related to these processes

Future work should examine interactions between the glutamatergic and opioidergic systems to better understand the potential synergistic or independent contributions of these systems to ketamine response