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Of note, in vitro experiments demonstrated that the increased pressure can trigger cancer cells to create autocrine gradients of CCR7 ligands and secrete them into the extracellular matrix (ECM), subsequently driving cancer LN metastasis via CCR7-dependent chemotaxis in the direction of flow toward functional lymphatic vessels (121)

Sterilization: If required, utilize aseptic processing techniques rather than heat sterilization to avoid thermal degradation

Vassiliy Tsytsarev, [email protected]