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GSTs were first recognized as enzymes inactivating xenobiotics, in particular electrophilic mutagens and carcinogens, leading to their excretion as mercapturic acids (Mannervik, 1985

More recent works conducted in primary human cell cultures, serum, and CSF have also been able to consistently define that the O -glycans attached to Thr194 are terminated with the maximum number of sialic acid residues per glycan (Sugano et al., 2008

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Consequently, drugs with anti-inflammatory actions are investigated for therapeutic or adjuvant use