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(Cockcroft-Gault (C-G), Modification of Diet in Renal Disease (MDRD), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI)) are more correctly regarded as measures of serum creatinine and/or cystatin C that have been adjusted for age, gender, and race, then factored to produce a numerical quantity similar to a measured GFR

The presence of an MTHFR polymorphism should therefore be viewed as one factor influencing methylation efficiency rather than evidence that folic acid is ineffective

Antioxidants and ROS inhibitors reduce oxidative damage, iron chelators limit iron-mediated toxicity, and GPX4 activators preserve cellular antioxidant capacity, collectively offering a multifaceted approach to suppressing ferroptosis in the injured lung