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Autoimmune sclerosing cholangitis or overlap syndrome Diagnosis: Autoimmune sclerosing cholangitis or overlap (ASC/overlap) syndrome is characterized by the concurrent presence of features of both AIH and PSC, the evidence of the latter may be in the form of large duct PSC based on abnormal cholangiography on imaging (magnetic resonance or endoscopic retrograde) or small-duct PSC based on onion skinning periductal fibrosis on histology

If treatment is recommended, a clinician evaluation and valid prescription are required

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Many patients were then told by their GP or nurse that their injections would be stopped for a year