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Nature 2018;556:515-519

Hicklin DJ, Ellis LM

10.1016/j.jtho.2019.04.007 77 JinS.DingX.YangC.LiW.DengM.LiaoH.et al (2021)

Firstly, the Xc system (solute carrier family 7 member 11 and family 3 member 2 (SLC7A11 and SLC3A2)) is responsible for taking up cystine to generate the substrate cysteine for the synthesis of GSH and is also involved in the formation of the GPX4 catalytic unit