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328 In ALS, HSBP8 protects against aggregation of TDP-43 and its cleavage products (TDP-25 and TDP-35) by promoting their removal via autophagy, further illustrating the tight functional coupling between sHSPs and degradative pathways

The intervention will be followed for one month

Both ALA and its reduced form DHLA act as potent antioxidants, capable of scavenging reactive oxygen species in various cellular compartments

Also, two open-label trials using 400 mg/day of riboflavin have decreased migraine attack frequency from 4 attacks per month to 2 attacks per month, and from 8.7 attacks per month to 2.9 attacks per month, respectively (100)