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Gore & Associates: Speaking and Teaching, Thomas Reiberger: Nothing to Disclose, Tim Hendrikx: Nothing to Disclose 1541 SINGLE-CELL RNA SEQUENCING ANALYSIS REVEALS SPECIFIC CELL SUBPOPULATIONS IN ALCOHOL-ASSOCIATED HEPATITIS CHARACTERIZED BY INFLAMMATORY, ANGIOGENIC AND FIBROGENIC PROFILE Elisa Pose 1 Alicia Martnez 2 Aina Rill-Hinarejos 3 Jordi Gratacs Gins 1 Silvia Ario 2 Martina Prez 1 Ana Rubio 2 Celia Martnez-Snchez 2 Ramon Bataller 1 Pere Gines 1 Elisabetta Mereu 3 MAR COLL 2 , 1 Liver Unit, Hospital Clnic Barcelona - Institut d'Investigacions Biomdiques August Pi i Sunyer, 2 Institut d'Investigacions Biomdiques August Pi i Sunyer, 3 Josep Carreras Leukemia Research Institute Background: The phenotypic alterations of the different cell types through Alcohol-associated liver disease (ALD) progression are largely unknown

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Robustness of cytosolic NADP redox homeostasis is conserved We next sought to understand to what extent the principles of NADP redox maintenance apply beyond yeast