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After Vpr stimulation, microglia exhibited increased translocation of inflammasome scaffold proteins from the nucleus to the cytoplasm, along with elevated levels of NLRP3, caspase-1, and IL-1 in both in vivo and in vitro settings [133] (Fig

A more individualized response-based approach monitors body composition changes and continues therapy as long as positive progress occurs, adjusting or pausing when plateaus develop or goals are achieved