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Lactate was also found to signal through specific G-protein coupled receptors expressed in neurons and glial cells, suggesting a possible role in neurotransmission, neurovascular coupling, and brain energy metabolism (Morland et al., 2015)

The handling Editor declared a shared affiliation, though no collaboration, with three of the authors, ZL, JQ, and JC, at the time of review

Moreover, a substantial methodological heterogeneity, including inconsistent protocols, lack of blinding, and unclear randomisation, limits the robustness of the conclusions

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