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Abbreviations ADI-R: Autism diagnostic interview - revised ALAD: Delta aminolevulinic acid dehydratase CARS: Childhood Autism Rating Scale CNS: Central nervous system d.f.: Degrees freedom DSM: American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders fGSH: Free reduced glutathione GCL: Glutamate cysteine ligase GCT: -glutamyl cyclotransferase GGT: -glutamyl-transferase GPx: Glutathione peroxidase GSH: Reduced glutathione GSH: GSSG: Glutathione redox ratio GSH-R: Glutathione reductase GS: Glutathione synthetase GSSG: Oxidised glutathione GST: Glutathione-S-transferases Mg 2+ : Magnesium ions Mn 2+ : Manganese ions Q: Cochran's Q (a measure of statistical heterogeneity) SMD: Standardised mean difference tGSH: Total glutathione References Wing L, Gould J: Severe impairments of social interaction and associated abnormalities in children: epidemiology and classification

Its given several times a week

This project was supported by the National Natural Science Foundation of China (823B2074 to P.C.T.), the National Key R&D Program of China (2022YFA1103704 to S.D.), Beijing Natural Science Foundation (JQ22016 to T.H.M.), the New Cornerstone Investigator Program (to S.D.), and Center for Life Sciences (to S.D.)