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If you recognize this picture, lab work is the next step not self-diagnosis and not a supplement shopping spree

Glutamine and monocyte/macrophage cell function Macrophages are associated with high consumption rates of glutamine and in addition, glutamine is essential for many of the functions of these leucocytes

One patient with severe knee and shoulder instability, for instance, received prolotherapy a few times per year over more than a decade and was able to continue working and stay active without recurrent dislocations

Notably, animal models have demonstrated that transferring dysbiotic microbiota from CFS/ME patients to germ-free mice can induce fatigue-like behaviors, supporting a causal role for the microbiome in disease pathogenesis (Bansal et al., 2025)