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Fura-2 emission was obtained by exciting alternatively at 340 and 380 nm with a rotating filter wheel (Sutter Instruments) and by monitoring emissions (F340 and F380) at 510 nm

Niacinamide (Vitamin B3) Reduces discoloration, improves skin texture, and strengthens skin barrier

Ethics declarations Funding Funding for this study was provided by Novo Nordisk A/S

24.2% weight loss at 48 weeks Massive metabolic improvements More research needed on long-term safety Other GLP-1/Glucagon Drugs Survodutide, Pemvidutide, and Cotadutide are in earlier or mid-stage development, with Survodutide showing the strongest results so far