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After 10 min of administration, the total radioactivity concentration increased significantly in all tissues, with the mean renal tissue concentration reaching 223 ng (Eq

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Per injection: 2 swabs 8 weeks (once daily): ~112 swabs 12 boxes Dosing Protocol A suggested daily injection approach based on common reference doses

When these affinity-enhancing mutations were added to full-length rat amylin, all three mutated rat amylin analogs showed enhanced potency for amylin receptor 1/2 activation by 5- to 10-fold compared to endogenous rat amylin and a clinical drug pramlintide (Figure 9A, 9B and Table 3)