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The Mayo Clinic shares that those most at risk of low levels include (5): people who dont consume enough vitamin B12 in their diet people diagnosed with pernicious anemia people whove had gastric surgeries people with intestinal issues, such as celiac or Crohns disease People following a vegetarian diet are especially at risk of deficiency

Interestingly, the liver, which is part of lean body mass, represents a larger proportion of total body weight in females

A wide range of payloads, from tiny radioactive imaging agents up to massive DNA-containing formulations, may be delivered to FR-positive cells using folate or an analog of it as the ligand

Wen and Rothenberg, 2016)