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A randomized, placebo-controlled, double-blind trial on type 2 diabetic patients administered 600 mg/d EPA and 300 mg/d DHA supplementation for 10 wks disclosed that their Nrf2 expression levels were higher than those of placebo-treated controls [71]

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Likewise, UFP-512 promotes a strong DOR endocytosis after 15 min exposure without significant desensitization on the cAMP pathway (Aguila et al., In contrast, the abolition of rKOR internalization by the S369A substitution also inhibits receptor desensitization on potassium currents (Mclaughlin et al., 2003)

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New England Journal of Medicine, 368(9), 814-823

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Rheumatology 57 , 508513 (2018)

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