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& Tinkov, A

Moreover, the CSF/serum ratio of phosphorylated Fetuin-A showed a significant positive correlation with the BBB permeability index, as measured by the CSF/serum albumin ratio [7]

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This exercise-responsive pattern led researchers to propose MOTS-c as a mitokine, a signaling molecule released by the mitochondria during physical exertion that mediates some of the systemic benefits of exercise