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The interaction of mitochondrial biogenesis and Fission/Fusion mediated by PGC-1alpha regulates Rotenone-Induced dopaminergic neurotoxicity

Ethical approval statement The Institutional Review Board of Ewha Womans University College of Medicine (2021-12-038) approved the analysis and provided a consent waiver as the data were anonymized and freely accessible by the NHIS for study purposes

Pharmacologic treatments for insomnia are meant to be used temporarily, as stated on the FDA label, and patients are advised not to use these medications for prolonged periods of time (Qaseem et al., 2016)

The sustained glucotoxic pancreatic microenvironment increases reactive oxygen species generation, resulting in chronic oxidative stress responsible for massive DNA damage