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doi: 10.1126/science.aar5551 148 LuoBGanWLiuZShenZWangJShiRet al

This in turn can produce toxic metabolites responsible for inhibiting CPS1

Additionally, altered microbial metabolism leads to elevated production of hepatotoxic SBA and dysregulated SCFA, which promote hepatic lipogenesis, OxE, and fibrosis [97]