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In states of high physiological demands like infancy, pregnancy, lactation, and old age, multiple reasons including malabsorption, dietary restrictions, lactose intolerance, food allergies, or cultural limitations forestall the uptake of the required amount of calcium

In this study, we demonstrate that cells harboring the Tibetan-specific M9a haplogroup with downregulated EPAS1 (M9a+sh EPAS1 ) exhibit enhanced cellular function under hypoxic conditions

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This observation was further confirmed by repeating the Cp1A assay with succinic acid- d 4 , which showed the incorporation of deuterium atoms into 3-NPH-fumaric acid (Supplementary Fig