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Mansi Chaudhari MBBS - General Medicine Last update on 01-Oct-2024

Similarly, as discussed previously, auranofin has demonstrated the ability to enhance T cell anti-tumor immunity in preclinical models and holds strong potential for repurposing as a cancer therapeutic, given its established use in rheumatoid arthritis (134)

A number of high-throughput screening studies have identified antagonists of the cGAS-STING pathway which have been demonstrated to either inhibit cGAS (103) or STING though competitively binding at the substrate binding sites (104) or induce conformation change (105) ( Figure 2B )

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