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Throughout evolutionary history, malaria-induced natural selection has profoundly influenced human genetic evolution, leading to the emergence of numerous genetic variations that confer resistance to the disease

Plus symbols indicate relative patterns of cochleotoxicity and vestibulotoxicity synthesized from patterns consistently reported across experimental hair-cell studies and clinical observational literature, rather than representing quantitative comparative effect sizes

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Synthetic lethal chemical screens in a panel of lung cancer cell lines and a normal epithelial cell line (BEAS-2B) with small-molecule drugs (n=22) targeting various oncogenic and metabolic pathways ( Supplementary Table 2 ) identified Erastin, an inhibitor of SLC7A11 and potent inducer of ferroptosis by blocking the uptake of cystine for GSH synthesis, that synergized with LDHB-specific siRNAs to suppress the viability of a subset of KRAS -mutant lung cancer cells (A549, H838, H460, H2122, and H2009), despite to a varied degree ( Figure 2a, b