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In preclinical studies of breast cancer cell lines, inhibition of PAR-1 resulted in a significant reduction in tumor growth and metastatic lesions [135137] (Figure 4)

Castagn V, Rougemont M, Cunod M, Do KQ

Therefore, it is essential to design intelligent nano delivery platforms to enhance the bioavailability of Cur and, at the same time, leverage combined therapeutic approaches to better address the complex tumor microenvironment in vivo