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During wound healing, it can be removed from existing extracellular proteins by proteolysis and used as a chemical attractant for inflammatory and endothelial cells It can increase the production of messenger RNA in collagen, elastin, proteoglycans and glycosaminoglycans in fibroblasts

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It is important to distinguish between excessive supplementation and pathologically elevated B12 levels, which may indicate underlying haematological disorders, liver disease, or renal impairment rather than true overdose

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