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J Nutr 66(2):291303 Mu Y, Xiang N, Zuo X, Yu X, Chen J (2021) Effects of total glucosides of Paeonia lactiflora on intestinal mucosal barrier and intestinal flora in rats with autoimmune thyroiditis

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Published data suggests up to 2.6% incidence of B12 deficiency within a year of treatment, and this figure climbs in patients who have used these medications long term or combined them with very low calorie diets (3)