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Laboratory animals were housed in polycarbonate (PC) cages under conventional laboratory conditions at 2024C, relative humidity of 4070%, and noise level of 60 dB

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Indeed, HGF protects BBB disruption after microsphere embolism-induced sustained cerebral ischemia by avoiding the inhibition of Bcl-2 (Date et al., 2006), thus decreasing apoptosis, and by reducing the expression of occludin and zonula occludens (ZO)-1, which are tight junction proteins, in cerebrovascular endothelial cells (Takeo et al., 2008)