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Since complex II dysfunction is noticed, a combined therapy containing cytochrome c, flavin mononucleotide, and thiamine diphosphate was attempted, which alleviated fatigability, motor disability, corneal edema, and chilblains in the patients, while no improvements were recorded with opthalmoplegia, blepharoptosis, or hearing loss [49]

A long time ago, pernicious anemia was fatal (pernicious means "deadly")

Deus HF, Stanislaus R, Behrens C, Wistuba II, Minna JD, Garner HR, Swisher SG , Roth JA, Correa AM, Broom B, Coombes K, Almeida JS

Together, these insights provide a conceptual foundation for developing next-generation precision therapies centered on the biology of inflammation resolution (Fig