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PMID: 26343946

[312] Consumption of coffee and tea, particularly 2-3 cups of coffee and more than 4 cups of tea per day, is associated with increased macular retinal nerve fiber layer (mRNFL) thickness, suggesting potential neuroprotective effects that warrant further investigation into causal links and mechanisms

In 2009 such defects were found to cause abnormal cytoskeletal rearrangement, leading to abnormal cell structure, defective migration and adhesion causing an autosomal recessive combined immunodeficiency

Such models are useful in studying metabolic and developmental consequences of thyroid hormone deficiencies, giving insight into how thyroid hormone insufficiency impacts growth and neurological function