melanotic schwannoma and melanoma A-D) Light microscopy findings of schwannoma. (A) The tumor A Rare Case of Aggressive

BBC Newshour, BBC World Service, December 4

Pagetoid melanocytosis has been used to describe lesions that exhibit pagetoid architecture (7)

Melanotan-2: The Shotgun Approach MT-2 hits the same MC1R receptor but also activates MC3R, MC4R, and MC5R : MC1R Melanin production (tanning) MC3R Energy homeostasis, cardiovascular function MC4R Sexual arousal, appetite regulation, erectile function MC5R Exocrine gland function, sebaceous secretion This non-selective binding is why MT-2 causes the "side effects" that many users actually seek out particularly the libido and appetite suppression effects

Several features distinguish this change from melanoma in situ (2) (Table 1, Figs