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Isolating and addressing potential confounding variables will make interpretation easier but also adds difficulty and considerable cost to a study

Neurochem Int 105790

Res Pharm Sci 12(5):425433 Ochiai RL et al (2008) A study of typhoid fever in five Asian countries: disease burden and implications for controls

As the global population ages, the prevalence of AD is rapidly increasing, imposing a significant burden on patients, caregivers, and healthcare systems