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, Koraichi, F., Chaudhary, A., Ganguly, K., Lockard, M.A., Favre, G., Terwilliger, T.C., Waldo, G.S

Notably, the presence of extracellular Ca 2+ above a threshold level is required for amino-acid-mediated CaSR activation, amino acids increase the sensitivity of the receptor toward Ca 2+

The mechanisms likely involve immune modulation (microglia in ALS can adopt a neurodegenerative phenotype that might be restrained by microbial signals) and metabolic support (providing nutrients like nicotinamide or SCFAs to neurons and glia) [214, 218]

These results indicate that the topical route is a promising alternative for combating localised oxidative stress, with potential application in various dermatological conditions related to redox imbalance [59]