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Only about 17% of patients under 10 years of age are found to have neuropsychiatric symptoms at presentation, whereas in patients presenting after 18 years of age, 74% experience neurologic manifestations.2,20 It is usually after 10 years of age that patients may manifest evidence of involvement of the other organ systems such as renal, hematologic, and endocrine (Figure 252)

Copper induces increased levels of inflammation in HepG2 ATP7B-KO cells To assess inflammatory responses, the expression of FOS , PLA2G2A , JUN , and JUNB was analysed in copper-treated HepG2 and HepG2 ATP7B-KO cells