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While its roles in nuclear factor erythroid 2-related factor 2 (Nrf2) activation and histone deacetylase (HDAC) inhibition are well-established, this review provides a novel synthesis by integrating disparate research scalesa multiscale perspective that spans from the genetic and epigenetic regulation of glucoraphanin biosynthesis in plants to SFNs recently elucidated effects on ferroptosis, cancer stem cells (CSCs), and the tumor immune microenvironment in humans

Estradiol replacement restores circulating levels to physiological or supraphysiological ranges depending on dose and delivery method, as demonstrated in multiple OVX rodent models

These cascades involve the activation of NF-B and MAPK pathways, upregulation of inflammatory cytokines, and overproduction of reactive oxygen species (ROS), collectively accelerating cellular senescence and tissue degradation 8,9,10,11,12