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Perhaps the most practical notion of whether a diet can be considered to be ketogenic is made by Seyfried (2012): it is as long as the individual has reduced blood glucose and is producing ketones. Although protein is included in the ketogenic ratio equation (Shaffer, 1921), glucose, ketone bodies, and their interplay determine the dominating metabolic mode: whether the predominant energy supply is glucose or ketone bodies (Westman et al., 2003)

Migration of epidermal keratinocytes: Mechanisms, regulation, and biological significance