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373 Future studies should integrate advanced technologies such as single-cell sequencing and spatial transcriptomics to characterize the dynamic changes and functional features of Tregs at various inflamed sites systematically, thereby laying the foundation for more precise therapeutic interventions

It addresses functional B-vitamin insufficiency, particularly during periods of stress or increased metabolic demand, while avoiding imbalance that can occur when single B vitamins are given in isolation

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8-OHdG Context: Reflects total body oxidative stress, not estrogen-specific, but reinforces metabolic-genotoxic overlap when paired with estrogen metabolite imbalances.