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3 Mechanisms of SIRT1 in cardiovascular diseases According to the World Heart Federation, there were 20.5 million deaths due to CVD in 2021, up from 12.1 million in 1990 (Shi et al., 2025)

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conventional medical therapy should raise 1989;85:301

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Calcium/calmodulin-dependent protein kinase IV suppresses IL-2 production and regulatory T cell activity in lupus

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J Lipid Res 50:15091520 Ilyin SE, Belkowski SM, Plata-Salamn CR (2004) Biomarker discovery and validation: technologies and integrative approaches

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