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When necessary, data were further normalized using MetaboAnalyst 5.0 97,98 , and scaled using GraphPad Prism (version 9.5.1, GraphPad Software)

Eur J Biochem 181:117

Acid dissociation constant (p K a )

Studies have shown that approximately 70% of breast cancer patients express estrogen receptor (ER)-positive, as estrogen is able to promote the proliferation of cancer cells and growth by activating ER (Hegde et al., 2021)