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Other studies have suggested that heme modifies cardiac contractile proteins through posttranslational protein modifications by consolidating with myosin light chain 1, which results in serious contractile heart dysfunction ( 2+ sensitivity (pCa50) ( 2+ homeostasis, and impairs systolic function ( In vitro , heme-treated adult rat cardiomyocytes have shown a significant reduction in systolic Ca 2+ transient amplitudes ( 2+ -handling proteins, such as the ryanodine receptor2 (RyR2) and the sarcoendoplasmic reticulum Ca2+-ATPase 2a (SERCA2a) (Khler et al., 2014), and may have activated intracellular stress kinases, such as calcium/calmodulin-dependent protein kinase II (CaMKII) ( 2+ mishandling

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doi: 10.3390/ijms222111359 218 SetiadiA

In both humans and rodents, acute bouts of endurance exercise typically elevate circulating irisin levels by 23-fold, with reported concentrations ranging from ~3 to 10 ng/mL in serum 34