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Correspondingly, melanocytes isolated from nonlesional skin and cultured in vitro have lower levels of catalase, heme-oxygenase (HO-1), superoxide dismutase 2 (SOD2), and ubiquinone expression [53,60]

An international, open-label, phase III trial (COLUMBUS [NCT01909453]) included 577 patients with stage IIIB, IIIC, or IV melanoma and BRAF V600 pathogenic variants