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Reduced PKM2 activity has been associated with enhanced cellular proliferation 152 , in agreement with earlier studies showing that posttranslational attenuation of PKM2 153 or its inhibition by oxidative stress 154 promotes tumor growth 155

Over the last two decades, many studies have examined the underlying mechanisms of curcumins antioxidant properties and its ability to scavenge free radicals, thus reducing cellular oxidative damage (27)