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Typically, the pain exhibits a unilateral nature, impacting one side of the head, and brings with it a suite of additional symptoms, such as photophobia (sensitivity to light), phonophobia (sensitivity to sound), nausea, and occasionally, vomiting

Disturbances of intestinal wall permeability can potentially lead to unwanted activation of the enteric immune system due to excessive contact with gut microbiota and its components, and the development of endotoxemia, when the level of bacterial lipopolysaccharides increases in the blood, causing chronic low-intensity inflammation

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