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Thus, cytopenias, splenomegaly, monoclonal gammopathy, bleeding, coagulation abnormalities, and hematological malignancies are part of the spectrum of hematological manifestations associated with IMD [2]

This, often absent in capillaries, is called the Virchow-Robin perivascular space, and it is filled with interstitial fluid that has lymphatic functions ( The BCSFB barrier is composed of an ependymal epithelium that produces the CSF, characterized by apical tight junctions located at the choroid plexuses

Thanks to decades of research, it is clear that PD exhibits considerable locus heterogeneity[4]

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